"Cleaner" then when that's done "Registry" and let it do its thing. After that "Auslogic Disc Defrag" and check off to 'Shut Down When Done'.
Every couple weeks or so do the CCleaner "Disc Wipe"; "simple", "one pass", which really digs to get what's down in the bilge and takes several hours but worth it. The only thing, if you want to be able to shut it down before going to bed that night you need to start around 5 or 6 pm that day. Or set your "Power Options" to shut the puter down later that night when you're sure it'll be done.
Next reboot it's like a new zesty machine rarin to go.